Genomes
- Potential for gene editing
- Everyone has the same genes, but most people have different alleles (variants)
- Benefits of finding your genome variants - disease related
- Protein structure can determine types of variants
- Carrying an allele can mean high risk but not guarantee a disease
- Genetics inform about ancestry
- There are lots of mutations, not all have an effect (eg cancer)
- Similar species have similar genomes
- Visualization is cool - circos plots - see variants, pathways, structural rearrangements
- How many variants cause a disease
- Different locations associated with a single disease / pathway / phenotype
- We now know links between genotype and phenotype (in human)
- We’re mostly the same genetically
- Lots of pathways - lots of genes for each - spread out
- Pleiotropy - one gene affects different phenotype
- We know certain alleles in genes and what they code for - phenotype
- Genotypes connected to career
- Microbiomes! There are whole communities of bacteria everywhere and we can now identify millions of them with genome sequencing